Comparison of transformations for single-cell rna-seq data

HIGHLIGHTS

• who: Constantin Ahlmann-Eltze from the (UNIVERSITY) have published the research: Comparison of transformations for single-cell RNA-seq data, in the Journal: (JOURNAL) of 25/08/2021
• what: The authors compare their strengths and weaknesses and find that the latter three have appealing theoretical properties; however, in benchmarks using simulated and real-world data, it turns out that a rather simple approach, namely, the logarithm with a pseudo-count followed by principal-component analysis, performs as well or better than the more sophisticated alternatives. A third set of transformations infers the parameters of a . . .
  

   

  

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