Complete loss of atm function augments replication catastrophe induced by atr inhibition and gemcitabine in pancreatic cancer models

HIGHLIGHTS

  • who: Charles R. Dunlop from the University of Cambridge, Cambridge, UK have published the paper: Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models, in the Journal: (JOURNAL) of 25/03/2020
  • how: Animal experiments All mouse experiments were carried out in the CRUK-CI BRU in accordance with the UK Animals (Scientific Procedures) Act 1986 with approval from the CRUK-CI Animal Welfare and Ethical Review Body.

SUMMARY

    Primary CLL cells with ATM defects showed enhanced sensitivity to AZD6738 compared to . . .

     

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