HIGHLIGHTS
SUMMARY
The cell-of-origin is defined as the normal cell that acquires the first cancer-promoting mutation(s) and refers to a cancer-initiating or tumor-initiating cell. Investigating the primary cells that are permissive to oncogenic drivers could pave the way for identifying the spectrum of cell-of-origin of STS, and shed light on the impact of this genetic/epigenetic crosstalk in determining tumor fate. The authors focus on how the mechanisms of cellular reprogramming, driven by a complex interplay between genetic and epigenetic changes can lead to misleading definition of the . . .
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