Comprehensive assessment of differential chip-seq tools guides optimal algorithm selection

HIGHLIGHTS

  • who: Thomas Eder from the Institute for Medical, Vienna, Vienna, Austria have published the research: Comprehensive assessment of differential ChIP-seq tools guides optimal algorithm selection, in the Journal: (JOURNAL)
  • what: The analysis provides unbiased guidelines for the optimized choice of software in differential ChIP-seq analysis. Establishing reference data and application of DCS tools To model the most relevant biological scenarios, the authors focused on three common shapes of ChIP-seq signals, representing transcription factors (TF) and two types of posttranslational histone modifications, as proposed by the Roadmap Epigenomics Consortium . Next, the authors focused . . .

     

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