HIGHLIGHTS
- who: Jeffrey K. Mak from the Department of Computer Science, University of Oxford, Parks Road, QD Oxford, UK have published the research: Comprehensive computational analysis of epigenetic descriptors affecting CRISPR-Cas9 off-target activity, in the Journal: (JOURNAL)
- what: In light of the above, the authors aim to conduct a comprehensive computational investigation on the impact of structural epigenetic features on CRISPR-Cas9 off-target activity.
- how: Next the authors evaluated the contribution of all epigenetic features in two successful machine/deep learning models which predict off-target activity. To investigate this further . . .
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