HIGHLIGHTS
- who: January and colleagues from the University of Liverpool, United Kingdom have published the article: Comprehensive in vitro and in silico assessments of metabolic capabilities of 24 genomic variants of CYP2C19 using two different substrates, in the Journal: (JOURNAL)
- what: Discussion: Therefore, the authors propose a methodology that combines in silico prediction algorithms and functional assays on polymorphic CYPs with multiple substrates to evaluate the changes in the metabolism of all possible genomic variants in CYP genes.
- how: The P450 contents was calculated from the absorbance at 450 and 490 nm using the . . .
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