HIGHLIGHTS
- who: Dominik Glodzik from the Department Lund University have published the research work: Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of March/31,/2015
- what: The authors demonstrate that BRCA1 hypermethylation is twice as frequent as BRCA1-null tumors in early-stage unselected TNBC and that elevated BRCA1 promoter methylation is detectable in peripheral blood DNA of patients with hypermethylation in the tumor. The authors show that in terms of mutational, epigenetic, transcriptional, and immune infiltration profiles, BRCA1 hypermethylation confers a tumor . . .
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