Comprehensive structural assignment of glycosaminoglycan oligo- and polysaccharides by protein nanopore

HIGHLIGHTS

  • who: Parisa Bayat from the (UNIVERSITY) have published the article: Comprehensive structural assignment of glycosaminoglycan oligo- and polysaccharides by protein nanopore, in the Journal: (JOURNAL) of 11/Nov/2021
  • what: The study reports the label-free detection and analysis of glycosaminoglycan molecules at the single molecule level using sensing by biological nanopore, thus addressing the need to decipher structural information in oligo- and polysaccharide sequences, which remains a major challenge for glycoscience. The authors demonstrate that a wild-type aerolysin nanopore can detect and characterize glycosaminoglycan oligosaccharides with various sulfate patterns, osidic bonds and epimers . . .

     

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