Comprehensive target screening and cellular profiling of the cancer-active compound b-ap15 indicate abrogation of protein homeostasis and organelle dysfunction as the primary mechanism of action

HIGHLIGHTS

• who: Johannes Gubat et al. from the Southern Illinois University Carbondale, United States have published the article: Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action, in the Journal: (JOURNAL)
• how: NGS data was analyzed with the MaGeCK software and by UMI lineage dropout analysis .

SUMMARY

In the previous decade, proteasome inhibitors have been successfully employed in the clinic, and agents that inhibit other UPS components are in various stages of development. b . . .

 



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