Computational discovery of cancer immunotherapy targets by intercellular crispr screens

HIGHLIGHTS

  • who: Soorin Yim from the Research Center, Daejeon, South Korea, Milner Therapeutics Institute, University of Cambridge, Cambridge, Cambridge, Cambridge, United Kingdom have published the research work: Computational Discovery of Cancer Immunotherapy Targets by Intercellular CRISPR Screens, in the Journal: (JOURNAL)
  • what: In the study by Dong et_al , single-cell_RNA_sequencing was used to identify genes expressed in CD8+ tumor-infiltrating lymphocytes. Identify Approved Targets for Cancer Immunotherapy To discover novel immunotherapeutic targets, the authors focused on intercellular interactions instead of single genes. The authors propose the use of intercellular CRISPR screens as a pipeline to discover . . .

     

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