Computational identification of clonal cells in single-cell crispr screens

HIGHLIGHTS

• who: Yihan Wang from the (UNIVERSITY) have published the Article: Computational identification of clonal cells in single-cell CRISPR screens, in the Journal: (JOURNAL)
• what: The authors show that the transcriptional similarities of clonally expanded cells contribute to false positives in single-cell CRISPR screens. The authors reason that the combination of sgRNAs in a cell can serve as a barcode to track clonal cells. The authors identified distinct populations of clonal cells, and the authors show that removal of clonal cells significantly reduces false discovery. The analysis shows that clone 18 exhibits clustered depletion . . .
  

   

  

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