HIGHLIGHTS
SUMMARY
One promising strategy to combat this phenomenon is the discovery of carbapenemase inhibitors through computational analyses. With the increased usage of these antimicrobial agents, resistance towards them through the production of carbapenemases, enzymes that can break down carbapenems by hydrolysis, has increased throughout the world. The spread of carbapenemase genes is also very concerning from a One Health perspective. Class A carbapenemases generally have a narrow active_site and are structurally similar to other non-carbapenemase members of class A β-lactamases. Class D carbapenemases have a generally weaker activity against carbapenems as compared with class . . .
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