Computational prediction and experimental validation of salmonella typhimurium sope-mediated fine-tuning of autophagy in intestinal epithelial cells

HIGHLIGHTS

• who: Amanda Demeter from the Affiliated Hospital of Guilin Medical, China have published the article: Computational prediction and experimental validation of Salmonella Typhimurium SopE-mediated fine-tuning of autophagy in intestinal epithelial cells, in the Journal: (JOURNAL)
• what: Similarly done to the experiment shown on Figure 4, HT-29 epithelial_cell monolayers were infected this time with either the strain lacking SifA only or the strain lacking both SifA and SopE. The authors propose that SopE induces autophagosome formation through SP1. The authors show that SopE dampens the autophagy flux.

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