HIGHLIGHTS
SUMMARY
The authors extend historical discussions on this topic (Adams et_al, 2016; Paulus et_al, 2016; Hitchcock et_al, 2022) by discussing the potential of integrative computational modeling for dementia research. For instance, early work like the "synaptic deletion and compensation" model (Horn et_al, 1993; Ruppin and Reggi, 1995) demonstrated that synaptic connections in Alzheimer`s disease are associated with memory loss and learning difficulties. Large-scale neural_network models address the links between psychiatric problems and information processing dysfunction intrinsic to large circuit functions (e_g, Raj and Itturia-Medina, 2019). Third, normative models address how the nervous . . .
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