Computational revision of the mechanism of the thorpe reaction “2279

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SUMMARY

    Sir Thorpe realized this reaction using a hot alcoholic dissolution to which was added the nitrile and realized this reaction using a hot alcoholic dissolution to which was added the nitrile and a acatalytic catalytic quantity of sodium ethoxide (EtONa). Tures of reactants, intermediates, transition_states, and products were constructed in a three-dimensional form in GaussView. The authors calculated geometry tures of reactants, intermediates, transition_states, and products were constructed in a optimizations and vibrational frequencies for all the structures involved in the three prothree-dimensional form in GaussView. It starts with thethe formation of . . .

     

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