Computationally profiling peptide:mhc recognition by t-cell receptors and t-cell receptor-mimetic antibodies

HIGHLIGHTS

• who: Matthew I. J. Raybould and colleagues from the Carlos III Health Institute (ISCIII), Spain University of Notre Dame have published the research: Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodies, in the Journal: (JOURNAL)

SUMMARY

The authors outline where and why TCRm:pMHC binding features tend to align with and differ from representative antibody:antigen and TCR:pMHC complexes. TCRm isolation strategies shifted towards the use of in_vitro phage-display libraries, both sidestepping the need to account for self-tolerance and enabling rounds of positive . . .

 



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