Computer-controlled closed-loop norepinephrine infusion system for automated control of mean arterial pressure in dogs under isoflurane-induced hypotension: a feasibility study

HIGHLIGHTS

• What: This study examined six consecutive female Beagle dogs aged 1.2 (1.1-1.3) years and weighing 9.1 (8.6-9.4) kg . The findings of this study indicate that titration of NE infusion rate by the system developed in this study led to the maintenance of MAP within ±5 mmHg of the predetermined target value for >85% of the observation period in five of six Beagle dogs with isoflurane-induced hypotension. The observation period of up to 30 min after system activation used in this study was short compared with those used in . . .
  

   

  

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