HIGHLIGHTS
- who: Matthias Baudot from the Institut have published the Article: Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity, in the Journal: Scientific Reports Scientific Reports of 29/07/2020
- what: The authors show for the first time that concomitant ablation of SAN-VGCCs disrupts heart automaticity and suppresses late diastolic LCRs, which are an important factor of the coupled clock pacemaker mechanism in SAN cells. Particularly, the authors show that Cav3.1 channels play an important role in stabilizing atrial and ventricular rhythmicity . . .
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