Concordance analysis of microsatellite instability status between polymerase chain reaction based testing and next generation sequencing for solid tumors

HIGHLIGHTS

• who: Keitaro Shimozaki from the DivisionKeio University have published the Article: Concordance analysis of microsatellite instability status between polymerase chain reaction based testing and next generation sequencing for solid tumors, in the Journal: Scientific Reports Scientific Reports
• how: The frequency and percentage of tumor samples with concordant and discordant MMR statuses based on PCR-based testing and NGS results were calculated after which the extent of concordance was tested using the Cohen κ correlation coefficient (κ) with its 95% CI maximum value κ (κmax) given the observed distribution and exact p value.

SUMMARY

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