HIGHLIGHTS
- who: Yihui Gu from the University of Minnesota Twin Cities, United States have published the research: Concurrent inhibition of FAK/SRC and MEK overcomes MEK inhibitor resistance in Neurofibromatosis Type I related malignant peripheral nerve sheath tumors, in the Journal: (JOURNAL)
- what: In MPNSTs, the research on the mechanisms underlying MEKi resistance was limited and mainly focused on the reactivation of receptor tyrosine kinases (RTK). The authors established MEKi-resistant MPNST_cell models and investigated the mechanism of MEKi resistance using high-throughput transcriptomic sequencing, aiming to improve the efficacy of MEKis in the treatment of . . .
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