Concurrent loss of mlh1, pms2 and msh6 immunoexpression in digestive system cancers indicating a widespread dysregulation in dna repair processes

HIGHLIGHTS

• who: Nic Gabriel Reitsam and colleagues from the AIMST University, Malaysia have published the Article: Concurrent loss of MLH1, PMS2 and MSH6 immunoexpression in digestive system cancers indicating a widespread dysregulation in DNA repair processes, in the Journal: (JOURNAL)
• what: The authors aim to shed light on features of this peculiar phenotype with an involvement of both MMR subsystems. The aim of this study was a comprehensive molecular characterization of digestive system cancer cases with concurrent, immunohistochemically detectable deficiencies in both DNA MMR subsystems. The study demonstrates that MLH1-/PMS2-/ MSH6- digestive system cancer cases . . .
  

   

  

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