Conformational cycle of human polyamine transporter atp13a2

HIGHLIGHTS

• who: Jianqiang Mu from the (UNIVERSITY) have published the paper: Conformational cycle of human polyamine transporter ATP13A2, in the Journal: (JOURNAL) of 28/03/2023
• what: To elucidate the conformational changes of hATP13A2 during a complete substrate transport process, the authors focused on the E1-ATP, the E2-Pi, and the putative E2 states, which have shown distinct conformational rearrangements (Fig 5).

SUMMARY

The AMP-PCP molecule tightly bound to the catalytic center in the E1-ATP state. Next, the authors used cross-linking mass spectrometry (XL-MS) to confirm potential . . .

 



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