HIGHLIGHTS
- who: Giuseppe Ermondi and colleagues from the Department of Molecular Biotechnology and Health Sciences, University of Torino, Quarello, Torino, Italy have published the research: Conformational Sampling Deciphers the Chameleonic Properties of a VHL-Based Degrader, in the Journal: Pharmaceutics 2023, 272 of /2023/
- what: The authors provide key points for tuning tools to reproduce PROTAC-1 chameleonicity according to NMR evidence. Specifically, the authors focus on three molecular descriptors: (a) the surface-accessible 3D polar surface area (3D PSA), (b) the radius of gyration (Rgyr ) , and_(c) the number of intramolecular hydrogen_bonds (nIMHB) . After the . . .
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