-conotoxins targeting the human voltage-gated sodium channel subtype nav1.7

HIGHLIGHTS

• who: Kirsten L. McMahon and colleagues from the Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia have published the Article: -Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype NaV1.7, in the Journal: Toxins 2022, 600 of /2022/
• what: The authors propose that this section contributes to the increased potency of these two µ-conotoxins at hNaV 1.7. The findings of this study provide valuable information for future design of hNaV 1.7 specific µ-conotoxin derived inhibitors.
• how: Interestingly the results are not in agreement with mammalian selectivity profiles . . .
  

   

  

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