Considering strategies for snp selection in genetic and polygenic risk scores

HIGHLIGHTS

  • who: Hypothesis et al. from the Center for Genomic Regulation (CRG), Spain Johns Hopkins University, United States have published the research work: Considering strategies for SNP selection in genetic and polygenic risk scores, in the Journal: (JOURNAL)
  • what: The authors discuss how SNP selection influences performance in different datasets and contexts. compelling rationale for differential score performance can be made for males versus females (Roberts et_al, 2020; Manikpurage et_al, 2021), since sex-specific disease incidence and regulation is the norm rather than the exception (Ober et_al, 2008). The authors examine whether obesity, as measured by . . .

     

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