Constitutive activation of the erk pathway in melanoma and skin melanocytes in grey horses

HIGHLIGHTS

• who: Melanoma and colleagues from the University, , have published the Article: Constitutive activation of the ERK pathway in melanoma and skin melanocytes in Grey horses, in the Journal: (JOURNAL)
• what: This study shows that the 4.6 kb duplication in STX17 in Grey horses is a novel mutation associated with constitutive activation of the ERK pathway in melanocytic cells.
• how: The authors therefore decided to directly manipulate the levels of RAS kinases by siRNA-based approach to address their potential contribution to the ERK1/2 pathway in GHM cells.
• future: Studies . . .
  

   

  

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