Construction and immunogenicity of a trypsin-independent porcine epidemic diarrhea virus variant

HIGHLIGHTS

• who: Mingxiang Li et al. from the Stanford University, United States have published the paper: Construction and immunogenicity of a trypsin-independent porcine epidemic diarrhea virus variant, in the Journal: (JOURNAL)
• what: The authors have demonstrated that the S2 (aa 894-1386) domain is the determinant of trypsin dependence of PEDV strain AJ1102.
• how: Trypsin-dependent strain AJ1102 but not trypsin-independent strain JS2008 Because the results showed that mutations at R894 and/or Y976 of the S protein did not alter the trypsin dependence of strain AJ1102 the authors constructed a chimeric . . .
  

   

  

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