Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid

HIGHLIGHTS

  • who: -dihydroxybutyric acid and collaborators from the Institute of Natural Materials Technology, TU Dresden, Dresden, Germany (TW.) have published the research work: Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 20/06/2017
  • what: The study demonstrates that the implementation of an efficient multistep non-natural DHB pathway is possible by applying design principles of synthetic biology, that is, conceptual pathway design and thermodynamic evaluation, computer-aided enzyme development, and strain engineering, in a straightforward manner. The . . .

     

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