HIGHLIGHTS
SUMMARY
Though the rapid advancement of endoscopic technology facilitates the early diagnosis of GC, the prognosis of patients has not significantly improved, owing to the non-specific symptoms and notorious aggressiveness of GC (Krejs, 2010; Li et_al, 2022a; He et_al, 2022). Anoikis is envisioned as a pivotal defense in combating tumor metastasis and maintaining normal tissue homeostasis (Kim et_al, 2012; Paoli et_al, 2013). Numbers of molecules and pathways have been confirmed to be involved in the anoikis resistance, which resulted in the metastasis and progression of GC (Li et_al, 2020b; Ye et_al, 2020; Zhang et_al . . .
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