Contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity

HIGHLIGHTS

• who: REPORT et al. from the X Institute (GmbH), Heidelberg, Germany have published the research: contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity, in the Journal: (JOURNAL) of 07/04/2023
• what: The authors show that alterations in the primary sequence of TLN1 via alternative splicing can also impact on the switch patterns.
• how: For this the authors used pan-cancer cell line CRISPR screen data from the DepMap project and correlated exon 17b expression with gene effect. For the single molecule experiments the authors used the R1-R3 triple . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.