Context-dependent dysregulation of transcription by mutant huntingtin*

HIGHLIGHTS

• who: Jonathan Cornett from the Jonathan Cornett, Lauren Smith, Meyer Friedman, Ji-Yeon Shin, Xiao-Jiang Li1, and Shi-Hua Li, From the Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia , Huntington disease (HD) is an adult-onset neurodegenerative disease caused by expansion of a polyglutamine (poly(Q) tract in the, terminal region of huntingtin (htt)Although the precise mechanisms leading to neurodegeneration in HD have not been fully elucidated, transcriptional dysregulation has been implicated in disease pathogenesis. In HD, multiple, terminal mutant htt fragments smaller than the first , amino acids have been found . . .
  

   

  

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