Contrasting epigenetic states of heterochromatin in the different types of mouse pluripotent stem cells

HIGHLIGHTS

• who: Matteo Tosolini from the (UNIVERSITY) have published the research: Contrasting epigenetic states of heterochromatin in the different types of mouse pluripotent stem cells, in the Journal: (JOURNAL) of 15/03/2018
• what: The authors show that 2i-ESCs are distinguished from other pluripotent cells by a prominent enrichment in H3K27me3 and low levels of DNA methylation at pericentromeric heterochromatin.
• how: The study now shows that none of the three repressive marks the authors examined exerts a direct repression on major satellite transcription in 2i-ESCs. Observations were carried out using a 63X . . .
  

   

  

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