Contribution of hif-p4h isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by hif-p4h-2 antagonism

HIGHLIGHTS

• who: Joona Tapio from the (UNIVERSITY) have published the research: Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism, in the Journal: (JOURNAL) of January/17,/2022
• what: The authors show both inhibitors induced a HIF response in wildtype white adipose_tissue (WAT), liver, and skeletal muscle and alleviated metabolic dysfunction during a 6-week treatment period, but they did not alter healthy metabolism. The authors demonstrate HIF-P4H-2 affected all tissues studied; its inhibition lowered body and liver weight and serum cholesterol levels and . . .
  

   

  

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