Contribution of infrared spectroscopy to the understanding of amyloid protein aggregation in complex systems

HIGHLIGHTS

  • who: Diletta Ami and colleagues from the Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano, Italy, Bioinformatics Consultant, Arquata have published the research: Contribution of Infrared Spectroscopy to the Understanding of Amyloid Protein Aggregation in Complex Systems, in the Journal: (JOURNAL)
  • how: As an example the authors exploited FTIR microspectroscopy combined with multivariate analysis to analyze in situ the spectral changes occurring in cultured intact HL-1 cardiomyocytes exposed to transthyretin (TTR)-wild_type (WT) or the highly amyloidogenic variant L55P-in native or amyloid-like conformations (Ami et_al 2018).
  • future: Interestingly . . .

     

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