Control of transcription elongation and dna repair by alarmone ppgpp

HIGHLIGHTS

• who: Jacob W. Weaver from the (UNIVERSITY) have published the article: Control of transcription elongation and DNA repair by alarmone ppGpp, in the Journal: (JOURNAL) of 27/02/2023
• what: The authors show that the latter is controlled via Site 1: a ppGpp-binding pocket of hitherto unknown function.
• how: To visualize the binding of ppGpp to elongating RNAP the authors conducted cryo-EM studies on a ppGpp-bound EC consisting of the five-subunit E. coli RNAP (u03b12u03b2u03b2u2032u03c9) bound to a nucleic_acid scaffold mimicking a transcription bubble.

SUMMARY

 



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