Controlling hypothalamic dna methylation at the pomc promoter does not regulate weight gain during the development of obesity

HIGHLIGHTS

• who: Taylor McFadden and collaborators from the Editor:, Indiana University Purdue have published the article: Controlling hypothalamic DNA methylation at the Pomc promoter does not regulate weight gain during the development of obesity, in the Journal: PLOS ONE of 12/Dec/2022
• what: We found that CRISPR-dCas9 mediated demethylation of the Pomc promoter was insufficient to prevent abnormal weight gain following acute exposure to an obesogenic diet.
• how: Time-course weight data was analyzed with twoway ANOVA and Fisher LSD posthoc tests.
• future: Regardless it is of critical importance in . . .
  

   

  

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