HIGHLIGHTS
- who: Soraya Learte-Aymamu00ed from the Departamento de Quu00edmica Universidade Compostela, Santiago de Compostela, Spain have published the research: Controlling oncogenic KRAS signaling pathways with a Palladium-responsive peptide, in the Journal: (JOURNAL) of 10/06/2022
- what: The authors show that the peptide u03b1H-His2 engineered to include two i i + 4 His chelating residues in a short fragment of the SOS1 u03b1H helix binds KRAS only after addition of a Pd(II) source. The authors demonstrate that such drastic preorganization is not required and that marginally stable helices can act as effective inhibitors . . .
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