HIGHLIGHTS
- who: Enrique Martin-Gayo from the University of the Witwatersrand, South Africa have published the research: Cooperation between cGAS and RIG-I sensing pathways enables improved innate recognition of HIV-1 by myeloid dendritic cells in elite controllers, in the Journal: (JOURNAL)
- what: The authors show that cell-intrinsic sensing of HIV-1 in mDC from EC can involve viral RNA and DNA replication products. The authors demonstrated that the expression of both cGAS and RIG-I, upstream of TBK1, was required for the improved innate recognition of HIV-1 dsDNA in HR-EC.
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