Cooperative insulation of regulatory domains by ctcf-dependent physical insulation and promoter competition

HIGHLIGHTS

• What: The authors show that developmental genes and nearby clusters of CTCF sites cooperatively foster the robust insulation of regulatory domains. By genetically dissecting a couple of representative loci in mouse embryonic stem_cells, the authors show that CTCF sites prevent undesirable enhancer-gene contacts (i.e. physical insulation), while developmental genes preferentially contribute to regulatory insulation through non-structural mechanisms involving promoter competition rather than enhancer blocking. The work provides important insights into the insulation of regulatory domains, which in turn might help interpreting the pathological consequences of certain structural variants. Most importantly, through the exhaustive genetic . . .
  

   

  

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