HIGHLIGHTS
- who: Kento Ojima from the Graduate School Nagoya University Tsukuba, Tsukuba, Japan have published the research work: Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 11/Oct/2021
- what: In the next step (i.e., 2nd screening), the authors aimed to find mGlu1 mutants activated by Pd(bpy) directly without potentiating the affinity of glutamate. With Pd(sulfo-bpy) showing low cytotoxicity in hand, the authors aimed to evaluate chemogenetic activation of endogenous mGlu1 to understand the physiological roles in the mouse brain . . .
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