Copper (i)-chloroquine complexes: interactions with dna and ferriprotoporphyrin, inhibition of -hematin formation and relation to antimalarial activity

HIGHLIGHTS

• who: Wilmer Villarreal et al. from the Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil have published the research work: Copper (I)-Chloroquine Complexes: Interactions with DNA and Ferriprotoporphyrin, Inhibition of -Hematin Formation and Relation to Antimalarial Activity, in the Journal: Pharmaceuticals 2022, 15, 921. of /2022/
• what: A new copper(I)-CQ complex, [Cu(CQ)(PPh3 )2 ]NO3 (1), was synthesized and characterized.
• how: Based on the above the authors evaluated the anti-plasmodial activity of two chloroquinecopper (I) complexes in_vitro and studied the possible mechanism of action using . . .
  

   

  

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