HIGHLIGHTS
SUMMARY
To reach this goal, the authors developed an SVZ-derived in_vitro neurosphere model and used the unique Cu chelating agent D-Pen to elucidate how Cu status determined the proliferation, migration, and differentiation of NPSCs in neurospheres. In Vitro Using thethe in in_vitro SVZ-derived the authors investigated investigatedthe theimpact impactofof Cu Using vitro SVZ-derivedneurosphere neurosphere model, model, the authors treatment on neurosphere migration as well as their differentiation into NeuN(+) neurons. The qPCR data from the in_vitro neurosphere studies clearly showed that the expression of some of these critical transcription factors was . . .
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