Core control principles of the eukaryotic cell cycle

HIGHLIGHTS

• who: Souradeep Basu from the Centrosomal , restricts, CDK , is located throughout the cell but is concentrated at the yeast centrosome (the spindle pole body, or SPB), which organizes the mitotic spindleGiven that cells expressing only, CDK struggle to construct mitotic spindles, we theorized that , may impose a CDK activity threshold specifically at the SPB, which, CDK is unable to surpass. If , at the SPB acts as an, CDK mitotic restriction factor, then removal of , located at the SPB should be sufficient for a, CDK-mediated mitosis. , localizes to the SPB through the SPB-localized adaptor protein Cut12 . . .
  

   

  

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