Coronary artery disease-associated lipa coding variant rs1051338 reduces lysosomal acid lipase levels and activity in lysosomes

HIGHLIGHTS

• who: Variant rs and colleagues from the (UNIVERSITY) have published the Article: Coronary Artery Disease-Associated LIPA Coding Variant rs1051338 Reduces Lysosomal Acid Lipase Levels and Activity in Lysosomes, in the Journal: (JOURNAL) of November/20,/2022
• what: The authors investigated the effect of the CAD-associated coding variant, rs1051338, and found that the risk allele caused an increased degradation of LAL, resulting in reduced lysosomal levels of LAL protein and reduced activity.
• future: The difference in effect size between monocytes and macrophages suggests some cell type- specific regulation of LIPA expression and . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.