Correlative light-electron microscopy using small gold nanoparticles as single probes

HIGHLIGHTS

• who: Iestyn Pope from the (UNIVERSITY) have published the Article: Correlative light-electron microscopy using small gold nanoparticles as single probes, in the Journal: (JOURNAL)
• what: The authors demonstrate a CLEM approach using small gold nanoparticles as a single probe. The authors demonstrate a CLEM workflow using individual small AuNPs as single probes of the epidermal growth factor (EGF) protein in mammalian cancer cells, imaged by FWM in LM and correlatively by transmission EM.
• future: Systematics can be improved in future experimental designs such that a correlation uncertainty eventually limited only by localisation . . .
  

   

  

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