Corticosteroid-binding globulin (cbg): spatiotemporal distribution of cortisol in sepsis

HIGHLIGHTS

• who: Jessica H. Lee from the DepartmentUniversity of Australia have published the article: Corticosteroid-binding globulin (CBG): spatiotemporal distribution of cortisol in sepsis, in the Journal: (JOURNAL)

SUMMARY

CBG concentrations and mortality risk after LPS were rescued by the restoration of CBG synthesis using adeno-associated virus serotype 8 (AAV8) CBG gene transfection in these KLF15-/- mice, highlighting the importance of CBG in surviving systemic inflammation. Under basal conditions, 80% of all cortisol in the circulation is bound to CBG, 15% to low affinity albumin, and the remaining 5% is unbound as biologically . . .

 



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