HIGHLIGHTS
SUMMARY
Patients were randomly assigned in a 1:1 ratio to receive 1 tablet containing 10 mg of enalapril and 0.8 mg of folic acid daily (single-pill compound, the enalapril-folic acid group) or 1 tablet containing 10 mg of enalapril daily (the enalapril group). After a median treatment duration of 4.5 years, the hazard ratio (HR) for occurrence of first stroke comparing enalapril-folic acid versus enalapril was 0.79 (95% CI: 0.68 to 0.93), with a 21% reduction in relative risk of first stroke, demonstrating that enalapril-folic . . .
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