HIGHLIGHTS
SUMMARY
To evaluate precision screening strategies with varied combinations of risk-stratification capability, different risk thresholds were selected for both models. The authors aim to evaluate the cost-effectiveness of this "two-step" model-based precision screening modality as compared to the currently used universal screening modality based on a large population-level screening cohort. When comparing the traditional strategy with "one-step" precision screening strategies (precision strategy_5~8), all three cost-effective strategies were precision screening strategies, including precision strategies_6 and amp; 5 applying model-based baseline screening at a sensitivity of 80% and . . .
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