Coupled binding and folding of disordered spin n-terminal region in myeloperoxidase inhibition

HIGHLIGHTS

  • who: . and collaborators from the Argonne National Laboratory (DOE), United States University of Gdansk, Poland have published the research: Coupled binding and folding of disordered SPIN N-terminal region in myeloperoxidase inhibition, in the Journal: (JOURNAL)
  • what: The authors focus on two SPIN homologs, SPIN-aureus and SPIN-delphini.
  • future: Experimental and/or computational studies will be required to further validate the above predictions.

SUMMARY

    Intrinsically disordered proteins/regions (IDPs/IDRs) like SPIN NTD are prevalent in biology and frequently play key roles in cellular regulation and signal_transduction (Wright . . .

     

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