Coupling metal and whole-cell catalysis to synthesize chiral alcohols

HIGHLIGHTS

  • who: Hang Yin from the (UNIVERSITY) have published the article: Coupling metal and whole-cell catalysis to synthesize chiral alcohols, in the Journal: (JOURNAL)
  • what: With dual advantages of cascade catalysis biocompatibility the work provides a rational strategy to harvest chiral alcohols in high yield excellent enantioselectivity as a channel to establish chemoenzymatic catalysis. The authors report a chemoenzymatic approach towards the synthesis of 4-chlorobenzhydrol, which combining Pd-catalyzed C-C formation and whole cell-catalyzed C=O reduction. The authors demonstrate the possibility of coupling of whole-cell catalysis and metal catalysis. After . . .

     

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